October 2023: Congratulations to Kailing on his co-first author paper entitled "Aspartyl-tRNA synthetase 2 orchestrates iron-sulfur metabolism in hematopoietic stem cells via fine-tuning alternative RNA splicing" published on Cell Reports recently. Thanks to Dr. Bin Guo for leading the project.
July 2023: Congratulations to Dr. Jun Wan on his new role as Associate Director for Collaborative Services for the Center for Computational Biology and Bioinformatics (CCBB) at IUSM.
July 2023: Congratulations to Dr. Jun Wan on his Showalter Faculty Scholar selected by IUSM and partially funded by the Ralph W. and Grace M. Showalter Research Trust Fund.
June 2023: Congratulations to all authors of the manuscript entitled "Lipid droplet-associated long non-coding RNA LIPTER preserves cardiac lipid metabolism" published online on Nature Cell Biology. Special thanks to Dr. Lei Yang for leading the whole project.
May 2023: Welcome Li Sun to join our lab as a research assistant. Li will become a Ph.D. student in the lab starting this Fall.
November 2022: Welcome Dr. Elnaz Pashaei to join our lab as a postdoctoral fellow!
August 2022: Welcome Sandali Dewni Lokuge to join our lab as a Ph.D. student!
August 2022: Our manuscript "Decoding Regulatory Associations of G-quadruplex with Epigenetic and Transcriptomic Functional Components" has been accepted for publication in Frontiers in Genetics. Congratulations and thanks to Shuyi and all co-authors!
August 2022: Xiashiyao Zhang joined our lab as a new Ph.D. student in bioinformatics. Welcome!
July 2022: Congratulations to Shuyi Fang on her successful thesis defense. Well done, Dr. Fang.
July 2022: Congratulations to Dr. Jun Wan on his tenure and promotion to Associate Professor.
April 2022: Welcome Dr. Shirzat Sulayman to join our lab as a postdoctoral fellow.
April 2022: Our GESS website has been upgraded to version 2 with multiple newly embedded functions, https://connect.posit.iu.edu/GESS/. Congratulations to Kailing and other co-authors on the new paper about GESS_v2 published on Frontiers in Medicine.
March 2022: Congratulations to Kailing on passing Ph.D. qualifying exam! Well done.
March 2022: Our other PRMT5 study which has been done together with Dr. Chang-Deng Hu's lab at Purdue University was published on Molecular Cancer Therapeutics. Congratulations to Sheng and all authors.
January 2022: Congratulations to Shuyi on passing her Ph.D. thesis proposal defense! Good job.
November 2021: The manuscript entitled "A survey on computational methods in discovering protein inhibitors of SARS-CoV-2" has been published on Briefings in Bioinformatics. Congratulations!
October 2021: Congratulations to Kailing on receiving the Best Presentation Award at the CCBB 2021 Retreat. Well done!
October 2021: Our manuscript "Updated SARS-CoV-2 Single Nucleotide Variants and Mortality Association" has been selected as cover image of Journal of Medical Virology. Thanks to all authors again and special thanks to Kailing and Audrey for the beatiful image design!
September 2021: Congratulations to Shuyi (co-first author) and Sheng on the paper entitled "ADGRG1 enriches for functional human hematopoietic stem cells following ex vivo expansion-induced mitochondrial oxidative stress" accepted for publication on Journal of Clinical Investigation. We do appreciate the collaboration with Dr. Bin Guo and all other authors.
July 2021: Congratulations to Yucheng on the paper entitled "Caspases switch off m6A RNA modification pathway to foster the replication of a ubiquitous human tumor virus" accepted for publication on mBio with Dr. Renfeng Li's lab from VCU. Good job!
July 2021: Congratulations to Shuyi, Sheng, and all authors on the paper entitled "Updated SARS-CoV-2 Single Nucleotide Variants and Mortality Association" accepted for publication on Journal of Medical Virology. Well done!
May 2021: Congratulations to Dr. Wan on his IUSCCC Near-Miss grant with Dr. Chang-Deng Hu!
November 2020: Congratulations to Shuyi on receiving the award of Best Oral Presentation at CCBB 2020 Retreat. Good job!
September 2020: Our paper entitled "GESS: A database of Global Evaluation of SARS-CoV-2/hCoV-19 Sequences" has been accepted for publication on Nucleic Acids Research. Congratulations to Shuyi, Kailing, Sheng, and all authors.
September 2020: Another PRMT5 work, "Protein arginine methyltransferase 5 promotes androgen receptor transcription in a pICln-dependent manner in castration-resistant prostate cancer", in collaboration with Dr. Chang-Deng Hu's lab has been accepted for publication on Cancer Research. Congratulations to Shuyi, Sheng, Dr. Hu's lab, and all authors.
September 2020: Our first COVID-19 paper entitled "Genetic spectrum and distinct evolution patterns of SARS-CoV-2" was accepted for publicatoin on Frontiers in Microbiology. Congratulations to Sheng, Shuyi, Kailing, and all our collaborators!
September 2020: Welcome Dr. Yucheng Zhang to join our lab from University of Florida.
July 2020: The paper in collaboration with Dr. Lei Yang’s lab entitled “Genome-wide studies reveal the essential and opposite roles of ARID1A in controlling human cardiogenesis and neurogenesis from pluripotent stem cells” was published online in Genome Biology. Congratulations to Sheng, Dr. Yang's lab, and all authors.
July 2020: Thanks to the Walther Cancer Foundation, IUSCCC, and IUSM for another five-year financial support on the C3B led by Dr. Jun Wan.
December 2019: Welcome Dr. Jilong Bian to join our lab. Dr. Bian is a visiting scholar from Northeast Forestry University. His research interest is about computer vision, deep learning and bioinformatics.
November 2019: Q&A with Dr. Jun Wan about the C3B was published in IUSCC news.
November 2019: In long-term collaboration with Dr. Chang-Deng Hu's lab at Purdue University, the paper entitled “PRMT5 cooperates with pICln to function as a master epigenetic activator of DNA double-strand break repair genes” was published in iScience. Congratulations to Sheng, Dr. Hu's lab, and all authors.
October 2019: Our teamwork together with Drs. Jingwu Xie and Jiali Han’s labs on “Distinct Transcriptomic Landscapes of Cutaneous Basal Cell Carcinomas and Squamous Cell Carcinomas” was published in Genes & Diseases. Congratulations to all authors!
August 2019: Our article "Follicular regulatory T cells inhibit the development of granzyme B–expressing follicular helper T cells" in collaboration with Dr. Alex Dent was published in JCI Insight. Congratulations to Shuyi and all authors.
September 2019: The featured interview with Dr. Nadia Atallah and Dr. Jun Wan at C3B, "A case for personalized medicine in the search for answers about cancer", was published in Purdue University Research Foundation News .
August 2019: Welcome Mr. Kailing Li to join our lab as a PhD student. Kailing received his master's degree in Computer Science from SUNY- University at Albany.
July 2019: Congratulations to our Indiana University Simon Cancer Center (IUSCC) for being promoted to NCI-comprehensive cancer center. The Cancer Bioinformatics Core led by Dr. Jun Wan is also successfully funded through CCGS grant for five more years.
July 2018: Another paper about our most recent study “Analysis of KLF4 regulated genes in cancer cells reveals a role of DNA methylation in promoter-enhancer interactions” has been published in Epigenetics. Congratulations!
August 2017: Welcome Ms. Shuyi Fang to join our lab as a PhD student. Shuyi got her bachelor's degree from Tongji University.
July 2017: Welcome Dr. Sheng Liu to join our lab as a research associate. Prior to Indiana University, Dr. Liu had postdoc training at Johns Hopkins University.
May 2017: Our study on KLF4 DNA methylation-dependent binding has been published in eLife. The paper was entitled “Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration”. Congratulations!
